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Proceedings Paper

Integrated optical coupling element for functional genomic analysis biosensor
Author(s): Corinne Vergnenegre; Charlotte Bringer; Veronique Bardinal; Thierry Camps; Chantal Fontaine; Antonio Munoz-Yague
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Paper Abstract

We present here a design of a coupling element aimed to be integrated into a nanomechanical biosensor for functional genomic analysis. The operation principle is based on a sub-nanometer resolution optical measurement of a cantilever deflection caused by a surface stress when the target nucleic acid sample hybridizes to the nucleic acid probe on the active side of the cantilever. The resulting deflection, of the order of nanometers, is measured by an optical system, in which a laser beam reflects off the back of the cantilever to a position sensitive photo-detector. We study in this paper three polymer optical coupling systems which could allow to detect the presence of target nucleic acid on the cantilever by amplifying the deflection caused by the stress.

Paper Details

Date Published: 18 February 2004
PDF: 9 pages
Proc. SPIE 5249, Optical Design and Engineering, (18 February 2004); doi: 10.1117/12.513289
Show Author Affiliations
Corinne Vergnenegre, LAAS-CNRS (France)
Charlotte Bringer, LAAS-CNRS (France)
Veronique Bardinal, LAAS-CNRS (France)
Thierry Camps, LAAS-CNRS (France)
Chantal Fontaine, LAAS-CNRS (France)
Antonio Munoz-Yague, LAAS-CNRS (France)

Published in SPIE Proceedings Vol. 5249:
Optical Design and Engineering
Laurent Mazuray; Philip J. Rogers; Rolf Wartmann, Editor(s)

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