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Proceedings Paper

Small-animal radionuclide imaging with focusing gamma-ray optics
Author(s): Michael J. Pivovaroff; William B. Barber; Finn Erland Christensen; William W. Craig; Todd Decker; Michael Epstein; Tobias Funk; Charles J. Hailey; Bruce H. Hasegawa; Randy Hill; Jesse G. Jernigan; C. Taylor; Klaus P. Ziock
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Paper Abstract

Significant effort currently is being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. While physiological function in small animals can be localized and imaged using conventional radionuclide imaging techniques such as single-photon emission tomography (SPECT) and positron emission tomography (PET), these techniques inherently are limited to spatial resolutions of 1-2 mm. For this reason, we are developing a small animal radionuclide imaging system (SARIS) using grazing incidence optics to focus gamma-rays emitted by 125I and other radiopharmaceuticals. We have developed a prototype optic with sufficient accuracy and precision to focus the 27.5 keV photons from 125I onto a high-resolution imaging detector. Experimental measurements from the prototype have demonstrated that the optic can focus X-rays from a microfocus X-ray tube to a spot having physical dimensions (approximately 1500 microns half-power diameter) consistent with those predicted by theory. Our theoretical and numerical analysis also indicate that an optic can be designed and build that ultimately can achieve 100 μm spatial resolution with sufficient efficiency to perform it in vivo single photon emission imaging studies in small animal.

Paper Details

Date Published: 30 December 2003
PDF: 15 pages
Proc. SPIE 5199, Penetrating Radiation Systems and Applications V, (30 December 2003); doi: 10.1117/12.511741
Show Author Affiliations
Michael J. Pivovaroff, Univ. of California/Berkeley (United States)
Lawrence Livermore National Lab. (United States)
William B. Barber, Univ. of California/San Francisco (United States)
Finn Erland Christensen, Danish Space Research Institute (Denmark)
William W. Craig, Lawrence Livermore National Lab. (United States)
Todd Decker, Lawrence Livermore National Lab. (United States)
Michael Epstein, Lawrence Livermore National Lab. (United States)
California Institute of Technology (United States)
Tobias Funk, Univ. of California/San Francisco (United States)
Charles J. Hailey, Columbia Univ. (United States)
Bruce H. Hasegawa, Univ. of California/San Francisco (United States)
Univ. of California/Berkeley (United States)
Randy Hill, Lawrence Livermore National Lab. (United States)
Jesse G. Jernigan, Univ. of California/Berkeley (United States)
C. Taylor, Columbia Univ. (United States)
Klaus P. Ziock, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 5199:
Penetrating Radiation Systems and Applications V
H. Bradford Barber; F. Patrick Doty; Hans Roehrig, Editor(s)

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