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Proceedings Paper

Incorporation of bioactive materials into integrated systems
Author(s): Bruce C. Bunker; Dale L. Huber; Ronald P. Manginell; Byung-Il Kim; Andrew K. Boal; George D. Bachand; Susan B. Rivera; Joseph M. Bauer; Carolyn M. Matzke
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Paper Abstract

Sandia is exploring two classes of integrated systems involving bioactive materials: 1) microfluidic systems that can be used to manipulate biomolecules for applications ranging from counter-terrorism to drug delivery systems, and 2) fluidic systems in which active biomolecules such as motor proteins provide specific functions such as active transport. An example of the first class involves the development of a reversible protein trap based on the integration of the thermally-switchable polymer poly(N-isopropylacrylamide)(PNIPAM) into a micro-hotplate device. To exemplify the second class, we describe the technical challenges associated with integrating microtubules and motor proteins into microfluidic systems for: 1) the active transport of nanoparticle cargo, or 2) templated growth of high-aspect ratio nanowires. These examples illustrate the functions of bioactive materials, synthesis and fabrication issues, mechanisms for switching surface chemistry and active transport, and new techniques such as the interfacial force microscope (IFM) that can be used to characterize bioactive surfaces.

Paper Details

Date Published: 15 October 2003
PDF: 9 pages
Proc. SPIE 5220, Nanofabrication Technologies, (15 October 2003); doi: 10.1117/12.509314
Show Author Affiliations
Bruce C. Bunker, Sandia National Labs. (United States)
Dale L. Huber, Sandia National Labs. (United States)
Ronald P. Manginell, Sandia National Labs. (United States)
Byung-Il Kim, Sandia National Labs. (United States)
Andrew K. Boal, Sandia National Labs. (United States)
George D. Bachand, Sandia National Labs. (United States)
Susan B. Rivera, Sandia National Labs. (United States)
Joseph M. Bauer, Sandia National Labs. (United States)
Carolyn M. Matzke, Sandia National Labs. (United States)

Published in SPIE Proceedings Vol. 5220:
Nanofabrication Technologies
Elizabeth A. Dobisz, Editor(s)

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