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Proceedings Paper

On the influence of the instillation time on the results of HAL (Hexvix) fluorescence detection of superficial bladder cancer
Author(s): Patrice Jichlinski; Daniela Aymon; Georges A. Wagnieres; Alexandre Marti; Norbert Lange; Louis Guillou; Hans-Juerg Leisinger; Hubert van den Bergh
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Paper Abstract

Hexyl aminolevulinate (HAL) fluorescence cystoscopy is being investigated as a new diagnostic tool for the detection of flat urothelial malignancies in bladder cancers. However, the influence of the bladder instillation time on the performance of this detection modality has not been addressed up to now. We report our initial experience comparing different instillation schedules of HAL cystoscopy in the diagnosis of superficial bladder cancer. A total of 718 fluorescent positive (433) and fluorescence negative (285) biopsies have been taken in the bladder of 143 patients using the Storz D-light fluorescence imaging system (Karl Storz, Tuttlingen, Germany) which allows both white and blue light (380-450 nm) bladder wall inspection. Following hospitalisation, 50 ml of HAL (8mM) phosphate buffer solution was instilled into the bladder of patients during one hour (1 hour protocol involving 57 patients), or during two hours followed by a two hours resting time after removal of the solution (2+2 hours protocol involving 86 patients). Both instillation subgroups were homogeneous in terms of proportion of high risk disease, previous BCG treatment and/or recurrent disease. This study indicates that the instillation duration does not influence the results of HAL (Hexvix) fluorescence cystoscopy in our conditions. Compared to the standard use of ALA, HAL (Hexvix) fluorescence cystoscopy allows a significant reduction of the instillation time (to less than one hour) without prejudicing the efficacy of the method, what represents a real advantage in daily clinical practice.

Paper Details

Date Published: 8 October 2003
PDF: 6 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.502218
Show Author Affiliations
Patrice Jichlinski, CHUV Univ. Hospital Lausanne (Switzerland)
Daniela Aymon, CHUV Univ. Hospital Lausanne (Switzerland)
Georges A. Wagnieres, Swiss Federal Institute of Technology, Lausanne (Switzerland)
Alexandre Marti, CHUV Univ. Hospital Lausanne (Switzerland)
Norbert Lange, Swiss Federal Institute of Technology, Lausanne (Switzerland)
Louis Guillou, CHUV Univ. Hospital Lausanne (Switzerland)
Hans-Juerg Leisinger, CHUV Univ. Hospital Lausanne (Switzerland)
Hubert van den Bergh, Swiss Federal Institute of Technology, Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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