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Proceedings Paper

Optical transillumination spectroscopy of breast tissue for cancer risk assessment
Author(s): Lothar Lilge; Kristina Blyschak; Michelle Simick; Roberta A. Jong
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Paper Abstract

Breast cancer is the most commonly occurring cancer in women. The lifetime risk of being diagnosed with breast cancer is approximately 1 in 10 thereby the highest out of all cancers. Breast cancer screening programs have been shown to decrease the mortality rates of women between ages 50-69, since cancers are detected at an earlier, more favourable stage. It is apparent that the development of breast cancer is a slow process following initial transformation of the breast tissue. Hence, there has been a strong effort within the research community to understand risk factors for the disease. Risk factors are defined as those characteristics that are more common in people with the disease when compared to the normal population. Quantification of an individual's breast cancer rate may lead that individual to modify her lifestyle and/or diet. Lifestyle changes could lead to a reduction in the incidence of breast cancer. Anatomically, the presence of increased amounts of fibroglandular tissue raises the estimated risk by up to 6 fold (correct for age), hence representing one of the strongest known risk factors pertaining to the entire female population. In this study the relative area of mammographic densities within a mammogram will be used as a global risk assessment tool. It has been shown previously that quantification of water, lipids, haemoglobin and other tissue chromophores of the optically interrogated breast tissue, which also gives rise to the mammographic densities, is feasible through near-infrared spectroscopy. Thus, the hypothesis for this study is that optical transillumination spectroscopy provides consistent and/or complementary information to conventional mammography in quantifying breast tissue density.

Paper Details

Date Published: 8 October 2003
PDF: 11 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.502109
Show Author Affiliations
Lothar Lilge, Ontario Cancer Institute, Univ. Health Network (Canada)
Univ. of Toronto (Canada)
Kristina Blyschak, Ontario Cancer Institute, Univ. Health Network (Canada)
Michelle Simick, Toronto-Sunnybrook Regional Cancer Ctr. (Canada)
Roberta A. Jong, Sunnybrook and Women's College Health Science Ctr. (Canada)

Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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