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Proceedings Paper

Fluorescence microscopy studies of a peripheral-benzodiazepine-receptor-targeted molecular probe for brain tumor imaging
Author(s): Laura Marcu; P. Thomas Vernier; H. Charles Manning; Sarah Salemi; Aimin Li; Cheryl M. Craft; Martin A. Gundersen; Darryl J. Bornhop
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Paper Abstract

This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

Paper Details

Date Published: 8 October 2003
PDF: 6 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.501033
Show Author Affiliations
Laura Marcu, Cedars-Sinai Medical Ctr. (United States)
Univ. of Southern California (United States)
P. Thomas Vernier, Univ. of Southern California (United States)
H. Charles Manning, Texas Tech Univ. (United States)
Sarah Salemi, Univ. of Southern California (United States)
Aimin Li, Keck School of Medicine (United States)
Univ. of Southern California (United States)
Cheryl M. Craft, Keck School of Medicine (United States)
Univ. of Southern California (United States)
Martin A. Gundersen, Univ. of Southern California (United States)
Darryl J. Bornhop, Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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