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Proceedings Paper

Lifetime fluorescence apparatus for clinical investigations of tissues
Author(s): Laura Marcu; Qiyin Fang; Thanassis Papaioannou; Javier A. Jo; Russel Vaitha; Kumar Shastry
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Paper Abstract

We report on the design, development, and performance of a versatile and mobile fiber-optic based time-resolved fluorescence apparatus for in-vivo spectroscopy of biological tissues. The apparatus is of modular design which allows for facile interfacing with different pulsed light sources and fiber-optic probes. Main features of the apparatus include: 1) fast acquisition of fluorescence decays with high temporal resolution (0.3 ns) for a broad range of emission wavelengths (300 to 850 nm) and lifetimes (0.3 ns to ms), 2) near real time analysis of fluorescence decays via a Laguerre deconvolution technique, and 3) compatibility with the clinical environment (endoscopic procedures or other intraoperative uses). The apparatus is currently employed for in-vivo studies of diseased tissues (cardiovascular and oncological applications).

Paper Details

Date Published: 8 October 2003
PDF: 7 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.501020
Show Author Affiliations
Laura Marcu, Cedars-Sinai Medical Ctr. (United States)
Univ. of Southern California (United States)
Qiyin Fang, Cedars-Sinai Medical Ctr. (United States)
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. (United States)
Javier A. Jo, Cedars-Sinai Medical Ctr. (United States)
Russel Vaitha, Cedars-Sinai Medical Ctr. (United States)
Univ. of Southern California (United States)
Kumar Shastry, Cedars-Sinai Medical Ctr. (United States)
Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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