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Proceedings Paper

Comprehensive description of light scattering by simultaneous measurement of angular, spectral, and polarization dependence for characterization of tissue macroachitecture in normal and precancerous states
Author(s): Young L. Kim; Yang Liu; Ramesh K. Wali; Hemant J. Roy; Michael J. Goldberg; Alexey K. Kromin; Kun Chen; Vadim Backman
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Paper Abstract

The most comprehensive description of light scattering was obtained by simultaneous measurement of its spectral, angular, azimuthal, and polarization characteristics. In studies with physical tissue models consisting of aqueous suspensions of microspheres, we showed that this comprehensive information reveals the properties of the internal structure of the samples. In the studies with a rodent model of colon carcinogenesis, we demonstrated the feasibility of detecting slight alterations of tissue micro-architecture by recording the multi-dimensional data characterizing tissue light scattering. We showed for the first time that such light scattering "fingerprinting" can be used to detect changes in tissue micro-architecture even at the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.

Paper Details

Date Published: 8 October 2003
PDF: 11 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.500880
Show Author Affiliations
Young L. Kim, Northwestern Unv. (United States)
Biomedical Engineering Department (United States)
Yang Liu, Northwestern Univ. (United States)
Biomedical Engineering Department (United States)
Ramesh K. Wali, Evanston Hospital, Northwestern Univ. (United States)
Department of Gastroenterology (United States)
Northwestern University (United States)
Hemant J. Roy, Evanston Hospital, Northwestern Univ. (United States)
Department of Gastroenterology (United States)
Northwestern University (United States)
Michael J. Goldberg, Evanston Hospital, Northwestern Univ. (United States)
Department of Gastroenterology (United States)
Northwestern University (United States)
Alexey K. Kromin, Northwestern Univ. (United States)
Biomedical Engineering Department (United States)
Kun Chen, Northwestern Univ. (United States)
Biomedical Engineering Department (United States)
Vadim Backman, Northwestern Univ. (United States)
Biomedical Engineering Department (United States)


Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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