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Proceedings Paper

Use of acousto-optic tunable filter in fluorescence imaging endoscopy
Author(s): Mounir Bouhifd; Maurice Whelan; Marc Aprahamian
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Paper Abstract

A prototype instrument for fluorescence-based medical diagnostics in vivo is described. The system consists of a rigid endoscope comprising a UV laser-source for fluorescence excitation and a white light source for direct imaging. An acousto-optic tuneable filter (AOTF) is employed as a full-field tuneable bandpass filter. This allows fast continuous or random-access tuning with high filtering efficiency. A study of the diagnostic potential of fluorescence imaging for pancreatitis was conducted on a rat model. In particular, the aim was to detect autofluorescence of endogenous protoporphyrin IX (PpIX) that has been shown to accumulate in early-stage diseased tissue undergoing an inflammatory response.

Paper Details

Date Published: 14 October 2003
PDF: 10 pages
Proc. SPIE 5143, Novel Optical Instrumentation for Biomedical Applications, (14 October 2003); doi: 10.1117/12.500700
Show Author Affiliations
Mounir Bouhifd, European Commission Joint Research Ctr. (Italy)
Maurice Whelan, European Commission Joint Research Ctr. (Italy)
Marc Aprahamian, INSERM (France)


Published in SPIE Proceedings Vol. 5143:
Novel Optical Instrumentation for Biomedical Applications
Albert-Claude Boccara, Editor(s)

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