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Proceedings Paper

Optical characterization of small biopsy samples
Author(s): Anikitos Garofalakis; Giannis Zacharakis; George Filippidis; Elias Sanidas; Dimitris D Tsiftsis; Eleftherios N Stathopoulos; Maria Kafousi; Theodore G. Papazoglou; Jorge Ripoll
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Paper Abstract

Optical characterization of biopsies can be used to discern between tissues when performing diffuse optical tomography of the female breast. The theory used for deriving the optical properties of such highly scattering media is based on the diffusion approximation. However, focusing the study in the regime of geometries comparable to the scattering mean free path, the diffusion approximation must be rearranged. Here we present several theoretical assumptions in this direction. In order to investigate the validity of the improved theory, experiments were made involving the transmittance of laser light through turbid phantom models. After the validation of our theoretical model, we have managed to derive the optical properties of over 50 excised breast tissue samples.

Paper Details

Date Published: 8 October 2003
PDF: 7 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.500546
Show Author Affiliations
Anikitos Garofalakis, Institute of Electronic Structure and Laser, FORTH (Greece)
Giannis Zacharakis, Institute of Electronic Structure and Laser, FORTH (Greece)
George Filippidis, Institute of Electronic Structure and Laser, FORTH (Greece)
Elias Sanidas, Univ. of Crete Medical School (Greece)
Dimitris D Tsiftsis, Univ. of Crete Medical School (Greece)
Eleftherios N Stathopoulos, Univ. of Crete Medical School (Greece)
Maria Kafousi, Univ. of Crete Medical School (Greece)
Theodore G. Papazoglou, Institute of Electronic Structure and Laser, FORTH (Greece)
Jorge Ripoll, Institute of Electronic Structure and Laser, FORTH (Greece)


Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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