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Proceedings Paper

Multiphoton imaging in the detection of malignancy in the oesophagus
Author(s): Catherine A. Kendall; Karen McCloskey; Nicholas Stone; Hugh Barr; Douglas Greenhalgh
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Paper Abstract

A preliminary investigation of tissue autofluorescence and uptake of the photosensitiser protoporphyrin IX (PpIX) has been investigated using multiphoton imaging of excised oesophageal tissue. The technique has indicated that changes in collagen structure may be a potential marker for high-grade dysplasia and adenocarcinoma. Changes in the localisation of PpIX with the development of malignancy in oesophageal tissue were also visualised.

Paper Details

Date Published: 9 October 2003
PDF: 5 pages
Proc. SPIE 5139, Confocal, Multiphoton, and Nonlinear Microscopic Imaging, (9 October 2003); doi: 10.1117/12.500486
Show Author Affiliations
Catherine A. Kendall, Gloucestershire Hopsitals NHS Trust (United Kingdom)
Karen McCloskey, Univ. of Strathclyde (United Kingdom)
Nicholas Stone, Gloucestershire Hopsitals NHS Trust (United Kingdom)
Hugh Barr, Gloucestershire Hopsitals NHS Trust (United Kingdom)
Douglas Greenhalgh, Gloucestershire Hospitals NHS Trust (United Kingdom)
Cranfield Univ. (United Kingdom)


Published in SPIE Proceedings Vol. 5139:
Confocal, Multiphoton, and Nonlinear Microscopic Imaging
Tony Wilson, Editor(s)

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