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Proceedings Paper

Functional brain imaging by CW-NIRS coregistered by blood flow monitors
Author(s): Jens M. Steinbrink; Florian Kempf; Stephan Schreiber; Kamil Uludag; Matthias Kohl; Jose M. Valdueza; Arno Villringer; Hellmuth Obrig
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Paper Abstract

Since a functional near-infrared spectroscopy monitor is a small and flexible tool, it can well be integrated with blood flow monitors. In the first part of the publication we show, that laser-doppler-flow measurements on the scalp return stimulus induced blood-volume changes. The effect of these changes on CW-NIRS measurements is demonstrated using frequency-domain-system capable of distinguishing absorption changes in superficial layers from those in the bulk tissue. The relationship between cerebral blood flow and cerebral hemoglobin concentration is studied in the second part of the publication. We present a visual stimulation experiment where changes in posterior cerebral artery flow velocity (PCA-Fv) were continuously monitored bilaterally by transcranial doppler sonography. Combining this approach with CW-NIRS imaging shows that the change in the arterial blood flow velocity occur approximately 1s before the deoxy-hemoglobin changes.

Paper Details

Date Published: 15 October 2003
PDF: 8 pages
Proc. SPIE 5138, Photon Migration and Diffuse-Light Imaging, (15 October 2003); doi: 10.1117/12.500479
Show Author Affiliations
Jens M. Steinbrink, Universitaetsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Florian Kempf, Universitaetsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Stephan Schreiber, Universitaetsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Kamil Uludag, Univ. of California, San Diego (United States)
Matthias Kohl, RheinAhrCampus (Germany)
Jose M. Valdueza, Universitaetsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Arno Villringer, Universitaetsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Hellmuth Obrig, Universitaetsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)


Published in SPIE Proceedings Vol. 5138:
Photon Migration and Diffuse-Light Imaging
David A. Boas, Editor(s)

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