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Proceedings Paper

Three-dimensional localization of fluorescent spots with adapted MUSIC algorithm
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Paper Abstract

We present a novel method, space-space MUSIC (MUltiple SIgnal Classification), to localize three-dimensionally focal fluorophore-tagged lesions activated subsequently by different laser source posi-tions from multi-sensor fluorescence data obtained from a single measurement plane. Matches between a signal subspace derived from the measured data and data from model spots allow 3D determination of the centers-of-gravity of fluorescence regions. Simulated spots in bounded, inho-mogeneous media could be localized accurately. The algorithm has shown to be robust against patient-dependent parameters, such as optical background parameters. The algorithm does also not consider medium boundaries.

Paper Details

Date Published: 15 October 2003
PDF: 12 pages
Proc. SPIE 5138, Photon Migration and Diffuse-Light Imaging, (15 October 2003); doi: 10.1117/12.500473
Show Author Affiliations
Bernhard Scholz, Siemens Medical Solutions (Germany)
Marcus Pfister, Siemens Medical Solutions (Germany)

Published in SPIE Proceedings Vol. 5138:
Photon Migration and Diffuse-Light Imaging
David A. Boas, Editor(s)

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