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Proceedings Paper

Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastases
Author(s): Jenny Smith; Catherine Kendall; Jay Christie-Brown; Alastair Sammon; Nicholas Stone
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Paper Abstract

Raman Spectroscopy is an optical diagnostic technique applied in this study to characterise breast tissue by biochemical signature spectra. In cross-validated results, Raman Spectroscopy identifies invasive breast carcinoma with 75 - 97% agreement with Histology opinion. Axillary lymph nodes from patients with breast carcinoma were mapped with confocal Raman Spectroscopy and colour-weighted principal component analysis (PCA) images were used to identify local biochemical features and correlate these with parallel section slides analysed with routine histology.

Paper Details

Date Published: 8 October 2003
PDF: 5 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.500472
Show Author Affiliations
Jenny Smith, Gloucestershire Royal Hospital (United Kingdom)
Catherine Kendall, Gloucestershire Royal Hospital (United Kingdom)
Jay Christie-Brown, Gloucestershire Royal Hospital (United Kingdom)
Alastair Sammon, Gloucestershire Royal Hospital (United Kingdom)
Nicholas Stone, Gloucestershire Royal Hospital (United Kingdom)


Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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