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Proceedings Paper

Near-infrared Raman spectroscopy to study the composition of human brain tissue and tumors
Author(s): Christoph Krafft; Snezana Miljanic; Stephan B. Sobottka; Gabriele Schackert; Reiner Salzer
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Paper Abstract

The composition of human brain tissue and brain tumors were studied by near infrared Raman spectroscopy with 785 nm excitation. The amounts of lipids, cholesterol, protein and water in fresh specimens were determined from Raman spectra by a combination of pure component spectra. Normal brain tissue was found to contain higher levels of lipids and cholesterol, brain tumors such as glioma and meningeoma displayed less lipids and cholesterol, but more proteins, in particular more hemoglobin-like molecules. These results demonstrate the applicability of Raman spectroscopy for real-time, in vivo, intraoperative diagnosis.

Paper Details

Date Published: 8 October 2003
PDF: 7 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.500469
Show Author Affiliations
Christoph Krafft, Dresden Univ. of Technology (Germany)
Snezana Miljanic, Dresden Univ. of Technology (Germany)
Stephan B. Sobottka, Univ. Hospital, Dresden Univ. of Technology (Germany)
Gabriele Schackert, Univ. Hospital, Dresden Univ. of Technology (Germany)
Reiner Salzer, Dresden Univ. of Technology (Germany)


Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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