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Proceedings Paper

Application of laser-induced autofluorescence spectra detection in human colorectal cancer screening
Author(s): Sheng Fu; Teck-Chee Chia; Leong Chuan Kwek; Cheong Hoong Diong; Choong Leong Tang; Francis Seow Choen; S. M. Krishnan
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Paper Abstract

We investigated 48 normal patients and 25 diseased patients using our laser-induced autofluorescence spectra detection system during their regular colonoscopy. The colon and rectum mucosa autofluorescence were excited by 405 nm continue wavelength laser. We observed that cancer or diseased colorectal mucosa, their autofluorescence spectra are significantly different from normal area. The autofluorescence spectra intensity at about 500 nm was been used for our intensity ratio characteristics intensity for our diagnostic algorithm. The intensity ratios of RI-680/I-500 and RI-630/I-500 were performed to identify the detection area. From experimental result we concluded that both intensity ratios of RI-680/I-500 and RI-630/I-500 as guidelines can detect cancerous and polyps disease completely. Our investigation provided some useful insight for laser induced autofluorescence spectra as a diagnosis technique for clinical application.

Paper Details

Date Published: 8 October 2003
PDF: 7 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.500455
Show Author Affiliations
Sheng Fu, Nanyang Technological Univ. (Singapore)
Teck-Chee Chia, Nanyang Technological Univ. (Singapore)
Leong Chuan Kwek, Nanyang Technological Univ. (Singapore)
Cheong Hoong Diong, Nanyang Technological Univ. (Singapore)
Choong Leong Tang, Singapore General Hospital (Singapore)
Francis Seow Choen, Singapore General Hospital (Singapore)
S. M. Krishnan, Nanyang Technological Univ. (Singapore)

Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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