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Proceedings Paper

LLNL Center for Microtechnology: capabilities, customers, case study -- HANAA (Handheld Nucleic Acid Analyzer)
Author(s): Raymond P. Mariella
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Paper Abstract

The polymerase chain reaction (PCR) is an enzyme-based chemical reaction that manufactures copies of one or more identifying regions of double-stranded DNA sequences (target sequences). These copies of target DNA are known as "amplicons". By creating millions of these copies of the identifying sequences (when they are present!), PCR allows researchers to detect by them, and hence the presence of the relevant organism, with techniques such as electrophoresis, flow cytometry, or spectrometry. Although there are numerous commercial PCR instruments that are designed for bench-top use in a laboratory, the challenges of building a battery-powered instrument that could perform such assays in the field.

Paper Details

Date Published: 18 June 2003
PDF: 12 pages
Proc. SPIE 5001, Optical Engineering at the Lawrence Livermore National Laboratory, (18 June 2003); doi: 10.1117/12.500360
Show Author Affiliations
Raymond P. Mariella, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 5001:
Optical Engineering at the Lawrence Livermore National Laboratory
Theodore T. Saito; Monya A. Lane, Editor(s)

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