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Proceedings Paper

Optical coherence tomography using tissue clearing for skin disease diagnosis
Author(s): Galina A. Petrova; Elena Derpalyuk; Natalia D. Gladkova; Felix I. Feldchtein; Nikolay Nikulin; Ekaterina Donchenko; Valentin M. Gelikonov; Vladislav A. Kamensky
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Paper Abstract

Capabilities of optical coherence tomography (OCT) as well as OCT enhanced by tissue clearing using glycerol solution for differential diagnosis of erythematoses, bullous and papulous skin diseases are demonstrated on 118 patients sample. It is shown that high-skilled dermatologists familiar with fundamentals of skin pathomorphology but without previous experience in OCT studies and interpretation of optical features are capable, when using OCT, of distinguishing optical images of various skin diseases to a high diagnostic accuracy (ranging from 76% to 94%) and with good multirater interobserver agreement between different specialists (kappa up to 0.69). Application of glycerol improves contrast and penetration depth of OCT images of skin significantly, thus reliably improving diagnostic validity of the technique and facilitating differential diagnosis of clinically similar dermatoses accompanied by papulous eruption.

Paper Details

Date Published: 2 October 2003
PDF: 10 pages
Proc. SPIE 5140, Optical Coherence Tomography and Coherence Techniques, (2 October 2003); doi: 10.1117/12.500159
Show Author Affiliations
Galina A. Petrova, Nizhny Novgorod Medical Academy (Russia)
Elena Derpalyuk, Nizhny Novgorod Research Dermatovenerological Institute (Russia)
Natalia D. Gladkova, Nizhny Novgorod Medical Academy (Russia)
Felix I. Feldchtein, Imalux Corp. (United States)
Institute of Applied Physics (Russia)
Nikolay Nikulin, Nizhny Novgorod Medical Academy (Russia)
Nizhny Novgorod Research Dermatovenerological Institute (Russia)
Ekaterina Donchenko, Nizhny Novgorod Institute for Trauma and Orthopedics (Russia)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Vladislav A. Kamensky, Institute of Applied Physics (Russia)


Published in SPIE Proceedings Vol. 5140:
Optical Coherence Tomography and Coherence Techniques
Wolfgang Drexler, Editor(s)

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