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Proceedings Paper

Fluorescence spectroscopy and imaging for noninvasive diagnostics: applications to early cancer detection in the lung
Author(s): Mary-Ann Mycek; Paul Urayama; Wei Zhong; Roger D. Sloboda; Konstantin H. Dragnev; Ethan Dmitrovsky
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Paper Abstract

Tissue fluorescence spectroscopy and imaging are being investigated as potential methods for non-invasive detection of pre-neoplastic change in the lung and other organ systems. A substantial contribution to tissue fluorescence is known to arise from endogenous cellular fluorophores. Using steady-state and time-resolved fluorescence spectroscopy and imaging, we characterized the endogenous fluorescence properties of immortalized and carcinogen-transformed human bronchial epithelial cells. Non-invasive sensing of endogenous molecular biomarkers associated with human bronchial pre-neoplasia will be discussed.

Paper Details

Date Published: 8 October 2003
PDF: 11 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.499867
Show Author Affiliations
Mary-Ann Mycek, Univ. of Michigan (United States)
Paul Urayama, Univ. of Michigan (United States)
Wei Zhong, Univ. of Michigan (United States)
Roger D. Sloboda, Dartmouth College (United States)
Konstantin H. Dragnev, Dartmouth Medical School (United States)
Ethan Dmitrovsky, Dartmouth Medical School (United States)

Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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