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Proceedings Paper

Accuracy of a simple diffusion model of fluorescence for estimating fluorophore concentration
Author(s): Kevin R. Diamond; Michael S Patterson; Thomas J Farrell
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Paper Abstract

Monte Carlo simulations and experiments in tissue-simulating phantoms were performed to study the accuracy of fluorophore concentrations recovered using a diffusion theory model of fluorescence. Fluorophore concentration was measured using three fluorophores with an overall root-mean-square accuracy of 13.7%. These experiments were compared with concentration measurements by diffuse reflectance spectroscopy, which were less accurate for all three fluorophores. Monte Carlo simulations were also used to examine the ability of the model to recover concentration from layered fluorophore distributions.

Paper Details

Date Published: 15 October 2003
PDF: 8 pages
Proc. SPIE 5138, Photon Migration and Diffuse-Light Imaging, (15 October 2003); doi: 10.1117/12.499820
Show Author Affiliations
Kevin R. Diamond, Hamilton Regional Cancer Ctr. (Canada)
McMaster Univ. (Canada)
Michael S Patterson, Hamilton Regional Cancer Ctr. (Canada)
McMaster Univ. (Canada)
Thomas J Farrell, Hamilton Regional Cancer Ctr. (Canada)
McMaster Univ. (Canada)

Published in SPIE Proceedings Vol. 5138:
Photon Migration and Diffuse-Light Imaging
David A. Boas, Editor(s)

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