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Proceedings Paper

Stochastic dynamics of enzymes: molecular scissors
Author(s): Olga A. Chichigina; Werner O. Ebeling; V. G. Makarov; Alexei V. Netrebko; Yury M. Romanovsky; Lutz Schimansky-Geier
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Paper Abstract

The problems studied here are relevant for an understanding of the functioning of hydrolytic enzyme molecules. These enzymes work like molecular machines breaking off the valence peptid bonds of substrates. In particular the role of Fermi resonance which is evident from a spectral lines of valence oscillations is studied. The influence of this resonance on valence splitting is discussed. It is shown that the breaking of these bonds has a higher probability, if the stochastic oscillations of atoms in catalytic groups at the active site have a large quality coefficient. We show that the corresponding low damping is essential for the Fermi resonance modes of these oscillations.

Paper Details

Date Published: 30 April 2003
PDF: 13 pages
Proc. SPIE 5110, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems, (30 April 2003); doi: 10.1117/12.497382
Show Author Affiliations
Olga A. Chichigina, M.V. Lomonosov Moscow State Univ. (Russia)
Werner O. Ebeling, Humboldt-Univ. zu Berlin (Germany)
V. G. Makarov, M.V. Lomonosov Moscow State Univ. (Russia)
Alexei V. Netrebko, M.V. Lomonosov Moscow State Univ. (Russia)
Yury M. Romanovsky, M.V. Lomonosov Moscow State Univ. (Russia)
Lutz Schimansky-Geier, Humboldt-Univ. zu Berlin (Germany)

Published in SPIE Proceedings Vol. 5110:
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov; Hans Frauenfelder; Frank Moss, Editor(s)

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