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Proceedings Paper

Protein noises
Author(s): Benjamin H. McMahon; Paul W. Fenimore; Montiago X. LaBute
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Paper Abstract

Diagrams of cellular processes present a clean, deterministic view of how biomolecules regulate the processes of life. Attempts to construct reaction networks which are true to the microscopic complexity of the system are intractable when only a few proteins are included. We argue here that several layers of microscopic modeling are needed to characterize the fluctuations, or noise, of biochemical systems and that this is necessary to develop predictive models of cellular processes. Our arguments are illustrated with the specific examples of myoglobin and protein kinases.

Paper Details

Date Published: 30 April 2003
PDF: 12 pages
Proc. SPIE 5110, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems, (30 April 2003); doi: 10.1117/12.497137
Show Author Affiliations
Benjamin H. McMahon, Los Alamos National Lab. (United States)
Paul W. Fenimore, Los Alamos National Lab. (United States)
Montiago X. LaBute, Los Alamos National Lab. (United States)


Published in SPIE Proceedings Vol. 5110:
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov; Hans Frauenfelder; Frank Moss, Editor(s)

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