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Proceedings Paper

Surface plasmon resonance imaging of Au nanoparticle-modified DNA monolayers
Author(s): Akira Yamaguchi; Masayuki Hayashida; Saulius Juodkazis; Yoichiro Hara; Shigeki Matsuo; Hiroaki Misawa
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Paper Abstract

A probe DNA monolayer modified with Au nano-particles was prepared on an Au thin film and used for DNA hybridization detection by surface plasmon resonance (SPR) spectroscopy. This Au particle modified probe DNA monolayer resulted in about a 3.5 times larger SPR angle shift according to the hybridization reaction, compared to that found in a non-modified probe DNA monolayer. By comparison of the SPR image of the particle modified and nonmodified probe DNA monolayer, this modification method was shown to be useful in improving the SPR signal for the detection ofthe unlabelled DNA molecules.

Paper Details

Date Published: 21 June 2002
PDF: 5 pages
Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); doi: 10.1117/12.491216
Show Author Affiliations
Akira Yamaguchi, Univ. of Tokushima (Japan)
Masayuki Hayashida, Univ. of Tokushima (Japan)
Saulius Juodkazis, Univ. of Tokushima (Japan)
Yoichiro Hara, Univ. of Tokushima (Japan)
Shigeki Matsuo, Univ. of Tokushima (Japan)
Hiroaki Misawa, Univ. of Tokushima (Japan)


Published in SPIE Proceedings Vol. 4626:
Biomedical Nanotechnology Architectures and Applications
Raymond P. Mariella; Michelle Palmer; Darryl J. Bornhop; Darryl J. Bornhop; Ramesh Raghavachari; Shuming Nie; Ramesh Raghavachari; Catherine J. Murphy; David A. Dunn; David A. Dunn; Raymond P. Mariella; Catherine J. Murphy; Dan V. Nicolau; Shuming Nie; Michelle Palmer; Ramesh Raghavachari, Editor(s)

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