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Proceedings Paper

Effect of low-power (He-Ne) laser on acute mucosal ulceration induced by indomethacin in rats
Author(s): Gholam-reza Esmaeeli Djavid; Rebecca Erfani; Nasim Amoohashemi; Mahbobeh Pazoki; Sanaz Aghaee; Hamidreza Pazoki Toroudi
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Paper Abstract

Background: Low-level laser has been used for treatment of ulcer, as well as, pain relief and inflammatory processes. In the present work, the effect of low power laser on mucosal gastric ulceration-induced by indomethacin in rats has been investigated. Materials and Methods: 16 male Sprague Dawley rats were divided into control (8 rats) and laser exposed group (8 rats). After using ether for anesthesia, 30 mg/kg indomethacin was injected subcutaneously. Exposed stomachs received 30 J He-Ne laser. Five hours later animals were killed and their stomachs were checked and observed for presence of ulceration. Results and Discussion: Gastric mucosal ulceration index was significantly greater in the laser-exposed group than control group. (P=0.02) This experiment suggests that low power He-Ne laser intensified acute mucosal ulcer formation by indomethacin. Changes in the prostaglandin content ofthe stomach may be responsible for these results.

Paper Details

Date Published: 15 October 2002
PDF: 4 pages
Proc. SPIE 4903, Laser Florence 2001: A Window on the Laser Medicine World, (15 October 2002); doi: 10.1117/12.486610
Show Author Affiliations
Gholam-reza Esmaeeli Djavid, Tehran Univ. of Medical Sciences (Iran)
Rebecca Erfani, Iran Univ. of Medical Sciences (Iran)
Nasim Amoohashemi, Iran Univ. of Medical Sciences (Iran)
Mahbobeh Pazoki, Iran Univ. of Medical Sciences (Iran)
Sanaz Aghaee, Iran Univ. of Medical Sciences (Iran)
Hamidreza Pazoki Toroudi, Iran Univ. of Medical Sciences (Iran)


Published in SPIE Proceedings Vol. 4903:
Laser Florence 2001: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R. A. Waidelich, Editor(s)

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