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Proceedings Paper

Measuring the effect of airway pressure on pulmonary arterial diameter in the intact rat lung
Author(s): Robert C. Molthen; Steven T. Haworth; Amy E. Heinrich; Christopher A. Dawson
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Paper Abstract

To study the relationship between transpulomnary pressure (Ptp), intravascular pressure (Pv), and the pulmonary arterial tree structure, morphometric measurements of pulmonary arterial trees were made in intact lungs from Sprague-Dawley rats. Using cone beam micro-CT and techniques we developed for imaging small animal lungs, volumetric CT data were acquired for Ptp from 0 - 12 mmHg and Pv from 5 - 30 mmHg. The diameter, D (measured range approximately 0.08-2.0 mm), vs. pressure, P, relation can be described by D(P) = D(0)(1+ α P), where α is a distensibility coefficient. Unlike studies performed in larger animals, where changes in either Ptp or Pv had nearly identical effect on vessel distensibility, we found that there is only a small dependence of arterial diameter on Ptp in the rat. For example, using the above relation where P=Ptp and Pv is held constant at 12mmHg, alpha = 0.55±0.42(SE) %/mmHg, compared with when P=Pv and Ptp is held at 12mmHg, alpha = 2.59±0.17(SE) %/mmHg.

Paper Details

Date Published: 2 May 2003
PDF: 9 pages
Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); doi: 10.1117/12.485800
Show Author Affiliations
Robert C. Molthen, Marquette Univ. (United States)
Medical College of Wisconsin (United States)
Zablocki VA Medical Ctr. (United States)
Steven T. Haworth, Medical College of Wisconsin (United States)
Amy E. Heinrich, Medical College of Wisconsin (United States)
Christopher A. Dawson, Marquette Univ. (United States)
Medical College of Wisconsin (United States)
Zablocki VA Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 5031:
Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
Anne V. Clough; Amir A. Amini, Editor(s)

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