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Proceedings Paper

Characterization of the second harmonic signal from collagen
Author(s): Guy C. Cox; Paul Xu; Colin J. R. Sheppard; John A. Ramshaw
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Paper Abstract

Collagen is known to be a very effective generator of the second harmonic of incident light from 700 to 1100nm, and second harmonic generation (SHG) microscopy is coming into use as a tool for studying the distribution of collagen in tissue. It also shows promise as a technique for characterizing collagen - both in distinguishing different collagen types and their packing and in identifying degradation of collagen in pathologic conditions. However many aspects of image formation in SHG microscopy of collagen remain imperfectly understood, and we have commenced a rigorous study of these factors. The present paper presents the first results from this program.

Paper Details

Date Published: 10 July 2003
PDF: 9 pages
Proc. SPIE 4963, Multiphoton Microscopy in the Biomedical Sciences III, (10 July 2003); doi: 10.1117/12.485598
Show Author Affiliations
Guy C. Cox, Univ. of Sydney (Australia)
Paul Xu, Univ. of Sydney (Australia)
Colin J. R. Sheppard, Univ. of Sydney (Australia)
John A. Ramshaw, CSIRO Molecular Science (Australia)

Published in SPIE Proceedings Vol. 4963:
Multiphoton Microscopy in the Biomedical Sciences III
Ammasi Periasamy; Peter T. C. So, Editor(s)

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