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Proceedings Paper

Animal model of photodynamic-therapy-induced esophageal stricture: preliminary report
Author(s): Yaron Perry; Michael W. Epperly; Sydney Finkelstein; Edwin Klein; Joel Greenberger; James Luketich
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Paper Abstract

Photodynamic Therapy (PDT) using Photofrin has been recently approved by the FDA for the treatment of esophageal cancer and Barrett's esophagus. A major limitation of PDT for Barrett's esophagus is the development of esophageal stricture in up to 53% of patients. Mechanisms of PDT stricture formation have not been elucidated. The major difficulty is the lack of an animal model for PDT-induced stricture. We have used a pig model in which the esophagus is very similar to that of the human esophagus. Two (Scrofa) domestic pigs were injected with Photofrin at dosage of 2 mg/kg 48 hours prior to photoactivation with 630 nm light. Following anesthesia, a laser probe (2.5 cm in length) was passed through the oral cavity to approximately the mid-point of the esophagus via an endoscope. Light energy (400 Joules (J)/cm) was delivered as a single dose in one pig or repeated at 72 hours in the second pig. In this pig model, upper endoscopy, Barium swallow and pathological studies confirmed stricture formation following esophageal PDT exposure of 400 J as one or two fractions. We believe that this is the first animal model created to study esophageal strictures resulting from PDT.

Paper Details

Date Published: 12 September 2003
PDF: 10 pages
Proc. SPIE 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII, (12 September 2003); doi: 10.1117/12.485327
Show Author Affiliations
Yaron Perry, Univ. of Pittsburgh Medical Ctr. (United States)
Michael W. Epperly, Univ. of Pittsburgh Medical Ctr. (United States)
Sydney Finkelstein, Univ. of Pittsburgh Medical Ctr. (United States)
Edwin Klein, Univ. of Pittsburgh Medical Ctr. (United States)
Joel Greenberger, Univ. of Pittsburgh Medical Ctr. (United States)
James Luketich, Univ. of Pittsburgh Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 4949:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII
Eugene A. Trowers; Lawrence S. Bass; Udayan K. Shah; Reza S. Malek; David S. Robinson; Kenton W. Gregory; Lawrence S. Bass; Abraham Katzir; Nikiforos Kollias; Hans-Dieter Reidenbach; Brian Jet-Fei Wong; Timothy A. Woodward; Werner T.W. de Riese; Keith D. Paulsen, Editor(s)

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