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Proceedings Paper

Measurement of the refractive index and aggregation of erythrocytes by the laser diffractometry method
Author(s): Stanislav S. Bessmeltsev; Alexander V. Lendiaev; A. U. Moskaleva; Vladimir Alexeevich Tarlykov; Irina G. Hodus
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Paper Abstract

The purpose of the present work is the experimental research of the possibility to use the laser diffraction method for determination of erythrocytes aggregation, erythrocyte refractive index and study of magnetic field influence on the erythrocytes (in vitro) in patients with multiple myeloid diseases. Changes in the refractive index of erythrocytes in patients with multiple myeloid and donors were experimentally analyzed by diffractometry. Essential differences in the refractive index ofMM patients and healthy persons were identified. Control measurements of erythrocytes aggregation degree were taken by microscopic method. Blood of 1 6 patients was studied. An increase in erythrocytes aggregation degree from 81 up to 99% was initially registered in all patients (average value is 90±3%). The influence of a permanent magnetic field on the erythrocytes (in vitro) was observed, for which purpose 3 sets of tests were conducted: in 8 of them a decrease in the aggregation degree from 3 up to 1 6 % was registered;in 4 tests no change was detected, while in 4 other tests an increase in the aggregation degree from 2 up to 13% was detected. The average value of the erythrocytes aggregation degree after the application of magnetic field was 93±8%. The obtained data serve as evidence to the positive influence of the permanent magnetic field on the erythrocytes aggregation as a whole, however the mechanism of such influence remains unclear. The undertaken research has proved the laser diffraction method to be perspective in medicine.

Paper Details

Date Published: 29 July 2002
PDF: 8 pages
Proc. SPIE 4900, Seventh International Symposium on Laser Metrology Applied to Science, Industry, and Everyday Life, (29 July 2002); doi: 10.1117/12.484499
Show Author Affiliations
Stanislav S. Bessmeltsev, Russian Research Institute of Hematology and Transfusiology (Russia)
Alexander V. Lendiaev, St. Petersburg Institute of Fine Mechanics and Optics (Russia)
A. U. Moskaleva, St. Petersburg Institute of Fine Mechanics and Optics (Russia)
Vladimir Alexeevich Tarlykov, St. Petersburg Institute of Fine Mechanics and Optics (Russia)
Irina G. Hodus, St. Petersburg Institute of Fine Mechanics and Optics (Russia)


Published in SPIE Proceedings Vol. 4900:
Seventh International Symposium on Laser Metrology Applied to Science, Industry, and Everyday Life
Yuri V. Chugui; Sergei N. Bagayev; Albert Weckenmann; P. Herbert Osanna, Editor(s)

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