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Proceedings Paper

Spectral staining of tumor tissue by fiber optic FTIR spectroscopy
Author(s): Reiner Salzer; Gerald Steiner; Angelique Kano; Tom Richter; Ralf Bergmann; Heike Rodig; Bernd Johannsen; Jens Kobelke
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Paper Abstract

Infrared (IR) optical fiber have aroused great interest in recent years because of their potential in in-vivo spectroscopy. This potential includes the ability to be flexible, small and to guide IR light in a very large range of wavelengths. Two types - silver halide and chalcogenide - infrared transmitting fibers are investigated in the detection of a malignant tumor. As a test sample for all types of fibers we used a thin section of an entire rat brain with glioblastoma. The fibers were connected with a common infrared microscope. Maps across the whole tissue section with more than 200 spectra were recorded by moving the sample with an XY stage. Data evaluation was performed using fuzzy c-means cluster analysis (FCM). The silver halide fibers provided excellent results. The tumor was clearly discernible from healthy tissue. Chalcogenide fibers are not suitable to distinguish tumor from normal tissue because the fiber has a very low transmittance in the important fingerprint region.

Paper Details

Date Published: 1 August 2003
PDF: 7 pages
Proc. SPIE 5047, Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II, (1 August 2003); doi: 10.1117/12.484153
Show Author Affiliations
Reiner Salzer, Technische Univ. Dresden (Germany)
Gerald Steiner, Technische Univ. Dresden (Germany)
Angelique Kano, Technische Univ. Dresden (Germany)
Tom Richter, Technische Univ. Dresden (Germany)
Ralf Bergmann, Research Ctr. Rossendorf (Germany)
Heike Rodig, Research Ctr. Rossendorf (Germany)
Bernd Johannsen, Research Ctr. Rossendorf (Germany)
Jens Kobelke, Institute for Physical High Technology (Germany)

Published in SPIE Proceedings Vol. 5047:
Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II
Tribikram Kundu, Editor(s)

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