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Proceedings Paper

Comparative studies on cervical and colonic malignancies using FTIR microspectroscopy
Author(s): Shaul Mordechai; Shlomo Mark; A. Podshyvalov; Keren Kantarovich; Y. Bernshtain; Ahmad Salman; Vitaly Erukhimovitch; Hugo Guterman; Jed Goldstein; Shmuel Argov; R. Jagannathan
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Paper Abstract

IR spectroscopy provides a new diagnostic tool due to its sensitivity to molecular composition and structure in cells, which accompany transformation from healthy to diseased state. The IR spectrum of a sample is, therefore, a biochemical fingerprint. It has been found that the most significant changes occur in the mid-IR spectral range 3-25 mm. Encouraging results have been reported in the literature on various types of cancers, such as human breast, lung, colon, cervical, and leukemia using FT-IR microspectroscopy. Much progress has also been made by several groups on IR spectral maps and IR imaging with good agreement between the data and the histopathological information. In an attempt to characterize healthy and diseased tissues, infrared microspectroscopy of cervical and colon human tissues was studied using an infrared microscopy. The comparative qualitative and quantitative changes detected using FTIR microspectroscopy are discussed.

Paper Details

Date Published: 1 August 2003
PDF: 9 pages
Proc. SPIE 5047, Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II, (1 August 2003); doi: 10.1117/12.484147
Show Author Affiliations
Shaul Mordechai, Ben-Gurion Univ. of the Negev (Israel)
Shlomo Mark, Ben-Gurion Univ. of the Negev (Israel)
A. Podshyvalov, Soroka Univ. Medical Ctr. (Israel)
Keren Kantarovich, Ben-Gurion Univ. of the Negev (Israel)
Y. Bernshtain, Ben-Gurion Univ. of the Negev (Israel)
Ahmad Salman, Ben-Gurion Univ. of the Negev (Israel)
Vitaly Erukhimovitch, Ben-Gurion Univ. of the Negev (Israel)
Hugo Guterman, Ben-Gurion Univ. of the Negev (Israel)
Jed Goldstein, Soroka Univ. Medical Ctr. (Israel)
Shmuel Argov, Soroka Univ. Medical Ctr. (Israel)
R. Jagannathan, Ben-Gurion Univ. of the Negev (Israel)


Published in SPIE Proceedings Vol. 5047:
Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II
Tribikram Kundu, Editor(s)

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