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Proceedings Paper

Improved instrumentation for photodynamic fluorescence detection of cancer
Author(s): Reinhold Baumgartner; Peter Heil; Dieter Jocham; M. Kriegmair; Herbert G. Stepp; Eberhard Unsoeld
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Paper Abstract

A fluorescence-detection technique for cancer in human hollow organs has been developed based on endoscope-assisted two-wavelength excitation of the polyporphyrin Photofrin II in tissue. Due to the photosensitizing capability of the fluorescent tumormarket the applied dose is reduced to 0.4 mg/kg bw which avoids photosensitization of the patient''s skin. Fluorescence is detected either spectrally resolved by means of an optical multichannel analyzer or by imaging of diseased tissue areas with an intensified video system. The fluorescence pattern in the final image is presented with high contrast due to realtime subtraction of nonspecific background signals.

Paper Details

Date Published: 1 November 1991
PDF: 3 pages
Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); doi: 10.1117/12.48231
Show Author Affiliations
Reinhold Baumgartner, GSF-Zentrales Laserlab. and Univ. Munich (Germany)
Peter Heil, GSF-Zentrales Laserlab. (Germany)
Dieter Jocham, Univ. Luebeck (Germany)
M. Kriegmair, Univ. Munich (Germany)
Herbert G. Stepp, GSF-Zentrales Laserlab. (Germany)
Eberhard Unsoeld, GSF-Zentrales Laserlab. (Germany)


Published in SPIE Proceedings Vol. 1525:
Future Trends in Biomedical Applications of Lasers
Lars Othar Svaasand, Editor(s)

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