Share Email Print
cover

Proceedings Paper

Application of the standard Hough transform to high-resolution MRI of human trabecular bone to predict mechanical strength
Author(s): Holger F. Bohm; Christoph Rath; Roberto A. Monetti; Dirk Muller; David Newitt; Sharmila Majumdar; Ernst J. Rummeny; Thomas M. Link
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this study we introduce two non-linear structural measures based on the Standard Hough-Transform (SHT) that are applied to high resolution MR-images of human trabecular bone specimens in order to predict biomechanical properties. The results are compared to bone mineral density (BMD) and linear morphometric parameters. Axial MR-images (voxel-size: 117x156x300 mm3) of 33 human femoral and 10 spinal specimens are obtained using a 3D-gradient-echo-sequence. After measurement of BMD by quantitative computed tomography (QCT) all specimens are tested destructively for maximum compressive strength (MCS). The SHT is applied to the binarized and Sobel-filtered images and the peak-value (maxH) and its corresponding bin (posH) of the normalized Hough-spectrum are determined as well as linear measures (apparent bone fraction (app.BV/TV), apparent trabecular separation (app.Tb.Sp), apparent trabecular perimeter per unit area (app.Tb.Perim)). For the spinal [femoral] specimens, R2 for MCS vs. maxH is 0.72 (p=0.004) [0.49 (p<0.001)], R2 for MCS vs. posH is 0.56 (p=0.013) [0.55 (p<0.001)], and R2 for MCS vs. BMD is 0.43 (p=0.041) [0.72 (p<0.001)]. Correlations of the conventional, linear morphometric parameters and MCS are lower than those for the SHT-based measures or BMD, ranging from 0.20 (p=0.003) for app.BV/TV to 0.46 (p<0.001) for app.Tb.Sp. Prediction of MCS by maxH, posH, or BMD alone is improved by combination with the linear morphometric parameters in a linear regressional model (R2 =0.79). In conclusion, the biomechanical strength of human trabecular bone in vitro can effectively be predicted from High-Resolution MR-images by structural measures based on SHT. In the vertebral specimens these are superior to BMD or conventional structural measures in predicting bone strength.

Paper Details

Date Published: 15 May 2003
PDF: 11 pages
Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); doi: 10.1117/12.481137
Show Author Affiliations
Holger F. Bohm, Technische Univ. Muchen (Germany)
Max-Planck-Institut für extraterrestrische Physik (Germany)
Christoph Rath, Technische Univ. Munchen (Germany)
Roberto A. Monetti, Technische Univ. Munchen (Germany)
Dirk Muller, Technische Univ. Munchen (Germany)
Max-Planck-Institut für extraterrestrische Physik (Germany)
David Newitt, Univ. of California/San Francisco (United States)
Sharmila Majumdar, Univ. of California/San Francisco (United States)
Ernst J. Rummeny, Technische Univ. Munchen (Germany)
Thomas M. Link, Technische Univ. Munchen (Germany)


Published in SPIE Proceedings Vol. 5032:
Medical Imaging 2003: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

© SPIE. Terms of Use
Back to Top