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Proceedings Paper

Estimation of pressure gradients at renal artery stenoses
Author(s): Peter J. Yim; Juan Raul Cebral; Ashley Weaver; Robert J. Lutz; G. Boudewijn C. Vasbinder
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Paper Abstract

Atherosclerotic disease of the renal artery can reduce the blood flow leading to renovascular hypertension and ischemic nephopathy. The kidney responds to a decrease in blood flow by activation of the renin-angiotensin system that increases blood pressure and can result in severe hypertension. Percutaneous translumenal angioplasty (PTA) may be indicated for treatment of renovascular hypertension (RVH). However, direct measurement of renal artery caliber and degree of stenosis has only moderate specificity for detection of RVH. A confounding factor in assessment of the proximal renal artery is that diffuse atherosclerotic disease of the distal branches of the renal artery can produce the same effect on blood-flow as atherosclerotic disease of the proximal renal artery. A methodology is proposed for estimation of pressure gradients at renal artery stenoses from magnetic resonance imaging that could improve the evaluation of renal artery disease. In the proposed methodology, pressure gradients are estimated using computational fluid dynamics (CFD) modeling. Realistic CFD models are constructed from images of vessel shape and measurements of blood-flow rates which are available from magnetic resonance angiography (MRA) and phase-contrast magnetic resonance (MR) imaging respectively. CFD measurement of renal artery pressure gradients has been validated in a physical flow-through model.

Paper Details

Date Published: 2 May 2003
PDF: 9 pages
Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); doi: 10.1117/12.480691
Show Author Affiliations
Peter J. Yim, Robert Wood Johnson Medical School (United States)
Juan Raul Cebral, George Mason Univ. (United States)
Ashley Weaver, National Institutes of Health (United States)
Robert J. Lutz, National Institutes of Health (United States)
G. Boudewijn C. Vasbinder, Maastricht Univ. Hospital (Netherlands)


Published in SPIE Proceedings Vol. 5031:
Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
Anne V. Clough; Amir A. Amini, Editor(s)

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