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Proceedings Paper

Development of contrast-enhanced rodent imaging using functional CT
Author(s): Yun Liang; Keith M. Stantz; Ganapathy Krishnamurthi; Rosemary Steinmetz; Gary D. Hutchins
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Paper Abstract

Micro-computed tomography (microCT) is capable of obtaining high-resolution images of skeletal tissues. However its image contrast among soft tissues remains inadequate for tumor detection. High speed functional computed tomography will be needed to image tumors by employing x-ray contrast medium. The functional microCT development will not only facilitate the image contrast enhancement among different tissues but also provide information of tumor physiology. To demonstrate the feasibility of functional CT in mouse imaging, sequential computed tomography is performed in mice after contrast material administration using a high-speed clinical CT scanner. Although the resolution of the clinical scanner is not sufficient to dissolve the anatomic details of rodents, bulky physiological parameters in major organs such as liver, kidney, pancreas, and ovaries (testicular) can be examined. For data analysis, a two-compartmental model is employed and implemented to characterize the tissue physiological parameters (regional blood flow, capillary permeability, and relative compartment volumes.) The measured contrast dynamics in kidneys are fitted with the compartmental model to derive the kidney tissue physiology. The study result suggests that it is feasible to extract mouse tissue physiology using functional CT imaging technology.

Paper Details

Date Published: 2 May 2003
PDF: 9 pages
Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); doi: 10.1117/12.480690
Show Author Affiliations
Yun Liang, Indiana Univ. School of Medicine (United States)
Keith M. Stantz, Indiana Univ. School of Medicine (United States)
Ganapathy Krishnamurthi, Purdue Univ. School of Health Sciences (United States)
Rosemary Steinmetz, Indiana Univ. School of Medicine (United States)
Gary D. Hutchins, Indiana Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 5031:
Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
Anne V. Clough; Amir A. Amini, Editor(s)

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