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Proceedings Paper

Monitoring the growth of tumors in the liver using dynamic CT
Author(s): Errol E. Stewart; Xiaogang Chen; Jennifer Hadway; Ting-Yim Lee
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Paper Abstract

Conventional CT imaging methods lack the accuracy that is necessary for detailed assessment of liver metastasis. However, quantitative measurement of hepatic perfusion has the potential to provide important information necessary for both the evaluation and treatment of liver metastasis. VX2 carcinoma cells were injected into the liver of healthy male rabbits. A two-phase scan protocol was used to acquire CT images for the determination of liver perfusion prior to and post implantation. Contrast enhancement curves from the aorta, portal vein and liver parenchyma were obtained from the reconstructed images. The weighted summation of the aortic and portal venous curve were de-convolved against the liver parenchymal curve to derive functional parameters such as total hepatic blood flow (HBF) and hepatic arterial fraction (HAF). Results show that the HAF of the implanted tumor increased throughout the period of the study. Twelve days after tumors were implanted the HAF in the liver significantly increased (P < 0.05) from the normal tissue value of 35 ± 1 to 57 ± 9 %. Functional maps of the HAF have the potential to improve treatment outcome of patients owing to the earlier diagnosis of liver cancer. We are able to detect VX2 tumors in the liver as early as 8 days after they were implanted.

Paper Details

Date Published: 2 May 2003
PDF: 9 pages
Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); doi: 10.1117/12.480419
Show Author Affiliations
Errol E. Stewart, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Robarts Research Institute (Canada)
Xiaogang Chen, Univ. of Western Ontario (Canada)
Jennifer Hadway, Lawson Health Research Institute (Canada)
Robarts Research Institute (Canada)
Ting-Yim Lee, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Robarts Research Institute (Canada)


Published in SPIE Proceedings Vol. 5031:
Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
Anne V. Clough; Amir A. Amini, Editor(s)

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