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Proceedings Paper

In-vivo fluorescence and reflectance imaging of human cervical tissue
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Paper Abstract

A hyperspectral imaging spectrograph has been used to measure the fluorescence and reflectance of cervical tissue in vivo. The instrument was employed in a clinical trial in Vilnius, Lithuania, where 111 patients were examined. The patients were initially screened by Pap smear, examined by colposcopy and a tissue sampling procedure was performed. Detailed histopathological assessments were performed on the biopsies, and these assessments were correlated with spectra and images. The results of the spectroscopic investigations show that different tissue types within one biopsy region exhibit different spectral signatures. A spectral analysis of the entire image localizes dysplastic regions in both fluorescence and reflectance, suggesting that the hyperspectral imaging technique is useful in the management of cervical malignancies.

Paper Details

Date Published: 2 May 2003
PDF: 10 pages
Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); doi: 10.1117/12.480413
Show Author Affiliations
Ulf P. Gustafsson, Science and Technology International (United States)
Elisabeth McLaughlin, Science and Technology International (United States)
Ellen Jacobsen, Science and Technology International (United States)
Johan Hakansson, Science and Technology International (United States)
Paul Troy, Science and Technology International (United States)
Michael James DeWeert, Science and Technology International (United States)
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Sara Palsson, Lund Institute of Technology (Sweden)
Marcelo Soto Thompson, Lund Institute of Technology (Sweden)
Sune Svanberg, Lund Institute of Technology (Sweden)
Aurelija Vaitkuviene, Vilnius Univ. Hospital (Lithuania)


Published in SPIE Proceedings Vol. 5031:
Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
Anne V. Clough; Amir A. Amini, Editor(s)

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