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Proceedings Paper

Biomechanical simulation of atrophy in MR images
Author(s): Andrew D. Castellano Smith; William R. Crum; Derek L. G. Hill; Neil A. Thacker; Paul A Bromiley
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Paper Abstract

Progressive cerebral atrophy is a physical component of the most common forms of dementia - Alzheimer's disease, vascular dementia, Lewy-Body disease and fronto-temporal dementia. We propose a phenomenological simulation of atrophy in MR images that provides gold-standard data; the origin and rate of progression of atrophy can be controlled and the resultant remodelling of brain structures is known. We simulate diffuse global atrophic change by generating global volumetric change in a physically realistic biomechanical model of the human brain. Thermal loads are applied to either single, or multiple, tissue types within the brain to drive tissue expansion or contraction. Mechanical readjustment is modelled using finite element methods (FEM). In this preliminary work we apply these techniques to the MNI brainweb phantom to produce new images exhibiting global diffuse atrophy. We compare the applied atrophy with that measured from the images using an established quantitative technique. Early results are encouraging and suggest that the model can be extended and used for validation of atrophy measurement techniques and non-rigid image registration, and for understanding the effect of atrophy on brain shape.

Paper Details

Date Published: 15 May 2003
PDF: 10 pages
Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); doi: 10.1117/12.480412
Show Author Affiliations
Andrew D. Castellano Smith, King's College London (United Kingdom)
William R. Crum, King's College London (United Kingdom)
Derek L. G. Hill, King's College London (United Kingdom)
Neil A. Thacker, Univ. of Manchester (United Kingdom)
Paul A Bromiley, Univ. of Manchester (United Kingdom)

Published in SPIE Proceedings Vol. 5032:
Medical Imaging 2003: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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