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Proceedings Paper

Registration of medical images using an interpolated closest point transform: method and validation
Author(s): Zhujiang Cao; Shiyan Pan; Rui Li; Ramya Balachandran; Michael J. Fitzpatrick; William C. Chapman; Benoit M. Dawant
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Paper Abstract

Image registration is an important procedure for medical diagnosis. Since the large inter-site retrospective validation study led by Fitzpatrick at Vanderbilt University, voxel-based methods and more specifically mutual information (MI) based registration methods have been regarded as the method of choice for rigid-body intra-subject registration problems. In this study we propose a method that is based on the iterative closest point (ICP) algorithm and a pre-computed closest point map obtained with a slight modification of the fast marching method proposed by Sethian. We also propose an interpolation scheme that allows us to find the corresponding points with a sub-voxel accuracy even though the closest point map is defined on a regular grid. The method has been tested both on synthetic and real images and registration results have been assessed quantitatively using the data set provided by the Retrospective Registration Evaluation Project. For these volumes, MR and CT head surfaces were extracted automatically using a level-set technique. Results show that on these data sets this registration method leads to accuracy numbers that are comparable to those obtained with voxel-based methods.

Paper Details

Date Published: 15 May 2003
PDF: 9 pages
Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); doi: 10.1117/12.480306
Show Author Affiliations
Zhujiang Cao, Vanderbilt Univ. (United States)
Shiyan Pan, LSI Logic Corp. (United States)
Rui Li, Vanderbilt Univ. (United States)
Ramya Balachandran, Vanderbilt Univ. (United States)
Michael J. Fitzpatrick, Vanderbilt Univ. (United States)
William C. Chapman, Washington Univ. (United States)
Benoit M. Dawant, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 5032:
Medical Imaging 2003: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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