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Proceedings Paper

Using normalization 3D model for automatic clinical brain quantative analysis and evaluation
Author(s): Hong-Dun Lin; Wei-Jen Yao; Wen-Ju Hwang; Being-Tau Chung; Kang-Ping Lin
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Paper Abstract

Functional medical imaging, such as PET or SPECT, is capable of revealing physiological functions of the brain, and has been broadly used in diagnosing brain disorders by clinically quantitative analysis for many years. In routine procedures, physicians manually select desired ROIs from structural MR images and then obtain physiological information from correspondent functional PET or SPECT images. The accuracy of quantitative analysis thus relies on that of the subjectively selected ROIs. Therefore, standardizing the analysis procedure is fundamental and important in improving the analysis outcome. In this paper, we propose and evaluate a normalization procedure with a standard 3D-brain model to achieve precise quantitative analysis. In the normalization process, the mutual information registration technique was applied for realigning functional medical images to standard structural medical images. Then, the standard 3D-brain model that shows well-defined brain regions was used, replacing the manual ROIs in the objective clinical analysis. To validate the performance, twenty cases of I-123 IBZM SPECT images were used in practical clinical evaluation. The results show that the quantitative analysis outcomes obtained from this automated method are in agreement with the clinical diagnosis evaluation score with less than 3% error in average. To sum up, the method takes advantage of obtaining precise VOIs, information automatically by well-defined standard 3-D brain model, sparing manually drawn ROIs slice by slice from structural medical images in traditional procedure. That is, the method not only can provide precise analysis results, but also improve the process rate for mass medical images in clinical.

Paper Details

Date Published: 2 May 2003
PDF: 9 pages
Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); doi: 10.1117/12.480288
Show Author Affiliations
Hong-Dun Lin, Chung Yuan Christian Univ. (Taiwan)
Industrial Technology Research Institute (Taiwan)
Wei-Jen Yao, National Cheng Kung Univ. Medical College (Taiwan)
Wen-Ju Hwang, National Cheng Kung Univ. Medical College (Taiwan)
Being-Tau Chung, Chung Yuan Christian Univ. (Taiwan)
Kang-Ping Lin, Chung Yuan Christian Univ. (Taiwan)
Industrial Technology Research Institute (Taiwan)

Published in SPIE Proceedings Vol. 5031:
Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
Anne V. Clough; Amir A. Amini, Editor(s)

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