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Proceedings Paper

Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation
Author(s): Suzanne T. Witt; Christian H. Riedel; Mario Goessl; Michael S. Chmelik; Erik Leo Ritman
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Paper Abstract

Micro-CT angiography of small laboratory mammal organs visualizes vascular branches on a large range of scales, ranging from root-level branches (~ 1 mm) to endarteriolar vessels (10-40 μm). Multiscale vascular tree segmentation is facilitated by the ability to set a single grayscale threshold value for vessels of all generation levels. Due to the non-ideal modulation transfer function (MTF) of the imaging system, object contrast varies significantly with scale, and the definition of a grayscale threshold for vessel segmentation becomes a problem. We found that performing a point spread function (PSF) deconvolution on the micro-CT projection images significantly reduces the thresholding problem in terms of restoring the smallest vessels' grayscale and delineation. The increased noise from performing a PSF deconvolution will not have a significant effect on the overall signal-to-noise ratio of the images. The PSF deconvolution was successful only when it accommodated the spatial variation of the PSF.

Paper Details

Date Published: 5 June 2003
PDF: 8 pages
Proc. SPIE 5030, Medical Imaging 2003: Physics of Medical Imaging, (5 June 2003); doi: 10.1117/12.480232
Show Author Affiliations
Suzanne T. Witt, Mayo Medical School (United States)
Christian H. Riedel, Mayo Medical School (United States)
Mario Goessl, Mayo Medical School (United States)
Michael S. Chmelik, Mayo Medical School (United States)
Erik Leo Ritman, Mayo Medical School (United States)

Published in SPIE Proceedings Vol. 5030:
Medical Imaging 2003: Physics of Medical Imaging
Martin J. Yaffe; Larry E. Antonuk, Editor(s)

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