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Proceedings Paper

Perfusion harmonic imaging of the human brain
Author(s): Volker H. Metzler; Guenter Seidel; Martin Wiesmann; Karsten Meyer; Til Aach
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Paper Abstract

The fast visualisation of cerebral microcirculation supports diagnosis of acute cerebrovascular diseases. However, the commonly used CT/MRI-based methods are time consuming and, moreover, costly. Therefore we propose an alternative approach to brain perfusion imaging by means of ultrasonography. In spite of the low signal/noise-ratio of transcranial ultrasound and the high impedance of the skull, flow images of cerebral blood flow can be derived by capturing the kinetics of appropriate contrast agents by harmonic ultrasound image sequences. In this paper we propose three different methods for human brain perfusion imaging, each of which yielding flow images indicating the status of the patient's cerebral microcirculation by visualising local flow parameters. Bolus harmonic imaging (BHI) displays the flow kinetics of bolus injections, while replenishment (RHI) and diminution harmonic imaging (DHI) compute flow characteristics from contrast agent continuous infusions. RHI measures the contrast agents kinetics in the influx phase and DHI displays the diminution kinetics of the contrast agent acquired from the decay phase. In clinical studies, BHI- and RHI-parameter images were found to represent comprehensive and reproducible distributions of physiological cerebral blood flow. For DHI it is shown, that bubble destruction and hence perfusion phenomena principally can be displayed. Generally, perfusion harmonic imaging enables reliable and fast bedside imaging of human brain perfusion. Due to its cost efficiency it complements cerebrovascular diagnostics by established CT/MRI-based methods.

Paper Details

Date Published: 23 May 2003
PDF: 12 pages
Proc. SPIE 5035, Medical Imaging 2003: Ultrasonic Imaging and Signal Processing, (23 May 2003); doi: 10.1117/12.479875
Show Author Affiliations
Volker H. Metzler, Univ. zu Lubeck (Germany)
Guenter Seidel, Universitatsklinikum Schleswig-Holstein/Lubeck (Germany)
Martin Wiesmann, Universitatsklinikum Schleswig-Holstein/Lubeck (Germany)
Karsten Meyer, Universitatsklinikum Schleswig-Holstein/Lubeck (Germany)
Til Aach, Univ. zu Lubeck (Germany)


Published in SPIE Proceedings Vol. 5035:
Medical Imaging 2003: Ultrasonic Imaging and Signal Processing
William F. Walker; Michael F. Insana, Editor(s)

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