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Proceedings Paper

Nonuniform tumor vascular oxygen dynamics monitored by three-channel near-infrared spectroscopy
Author(s): Jae G Kim; Yueqing Gu; Anca Constantinescu; Ralph P. Mason; Hanli Liu
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Paper Abstract

In a previous report, we showed that there was distinct heterogeneity in tumor oxygenation dynamics even within the same tumor monitored by F MR pO2 mapping and near-infrared spectroscopy (NIRS). In this study, we applied a three-channel NIRS system to reveal dynamic heterogeneity of tumor vascular oxygenation during respiratory challenges. When the implanted tumors reached ~3 cm, three photo detectors were attached to the surface of the tumor in three different positions to measure changes in oxygenated hemoglobin concentration ([HbO2]), while the inhaled gas was alternated between air and carbogen (95% O2 + 5% CO2). Significant changes in tumor oxygenation were observed at all three detectors accompanying the respiratory challenge, and these changes could be modeled with two exponential components with fast and slow time constants. Time constant, amplitude, vascular coefficient, and the ratio of perfusion rate were obtained from fitting curve of Δ[HbO2]. These parameters revealed that there were indeed different responses of tumor vascular oxygenation during carbogen inhalation at the three different locations. These results clearly reveal that tumors are highly heterogeneous during vascular oxygenation in response to carbogen inhalation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive way for monitoring tumor physiology, and it may have prognostic value, providing insight into tumor vascular development and angiogenesis.

Paper Details

Date Published: 29 July 2003
PDF: 9 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.479800
Show Author Affiliations
Jae G Kim, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Univ. of Texas at Arlington (United States)
Yueqing Gu, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Univ. of Texas at Arlington (United States)
Anca Constantinescu, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Ralph P. Mason, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Hanli Liu, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Univ. of Texas at Arlington (United States)


Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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