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Proceedings Paper

Diffuse optical tomography with a priori anatomical information
Author(s): Murat Guven; Birsen Yazici; Xavier Intes; Britton Chance
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Paper Abstract

Diffuse optical imaging is an emerging modality that uses Near Infrared (NIR) light to reveal structural and functional information of deep biological tissue. It provides contrast mechanisms for molecular, chemical, and anatomical imaging that is not available from other imaging modalities. Diffuse Optical Tomography (DOT) deals with 3D reconstruction of optical properties of tissue given the measurements and a forward model of photon propagation. DOT has inherently low spatial resolution due to diffuse nature of photons. In this work, we focus to improve the spatial resolution and the quantitative accuracy of DOT by using a priori anatomical information specific to unknown image. Such specific a priori information can be obtained from a secondary high-resolution imaging modality such as Magnetic Resonance (MR) or X-ray. Image reconstruction is formulated within a Bayesian framework to determine the spatial distribution of the absorption coefficients of the medium. A spatially varying a priori probability density function is designed based on the segmented anatomical information. Conjugate gradient method is utilized to solve the resulting optimization problem. Proposed method is evaluated using simulation and phantom measurements collected with a novel time-resolved optical imaging system. Results demonstrate that the proposed method leads to improved spatial resolution, quantitative accuracy and faster convergence than standard least squares approach.

Paper Details

Date Published: 29 July 2003
PDF: 13 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.479799
Show Author Affiliations
Murat Guven, Drexel Univ. (United States)
Birsen Yazici, Drexel Univ. (United States)
Xavier Intes, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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