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Proceedings Paper

Fluorescence and reflectance monitoring of human cervical tissue in vivo: a case study
Author(s): Ulf P. Gustafsson; Elisabeth McLaughlin; Ellen Jacobson; Johan Håkansson; Paul Troy; Michael James DeWeert; Sara Pålsson; Marcelo Soto Thompson; Sune Svanberg; Aurelija Vatkuviene; Katarina Svanberg
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Paper Abstract

An imaging spectrograph, designed and built by Science and Technology International (STI), and a point monitoring system, developed at the Lund Institute of Technology, have been used to measure the fluorescence and reflectance of cervical tissue in vivo. The instruments have been employed in a clinical trial in Vilnius, Lithuania, where 111 patients were examined. Patients were initially screened by Pap smear, examined by colposcopy and a tissue sampling procedure was performed. Detailed histopathological assessments were performed on the biopsies, and these assessments were correlated with spectra and images. The results of the spectroscopic investigations are illustrated by a thorough discussion of a case study for one of the patients, suggesting that the techniques are useful in the management of cervical malignancies.

Paper Details

Date Published: 2 July 2003
PDF: 11 pages
Proc. SPIE 4959, Spectral Imaging: Instrumentation, Applications, and Analysis II, (2 July 2003); doi: 10.1117/12.479495
Show Author Affiliations
Ulf P. Gustafsson, Science and Technology International (United States)
Elisabeth McLaughlin, Science and Technology International (United States)
Ellen Jacobson, Science and Technology International (United States)
Johan Håkansson, Science and Technology International (United States)
Paul Troy, Science and Technology International (United States)
Michael James DeWeert, Science and Technology International (United States)
Sara Pålsson, Lund Institute of Technology (Sweden)
Marcelo Soto Thompson, Lund Institute of Technology (Sweden)
Sune Svanberg, Lund Institute of Technology (Sweden)
Aurelija Vatkuviene, Vilnius Univ. Hospital (Lithuania)
Katarina Svanberg, Lund Univ. Hospital (Sweden)


Published in SPIE Proceedings Vol. 4959:
Spectral Imaging: Instrumentation, Applications, and Analysis II
Richard M. Levenson; Gregory H. Bearman; Anita Mahadevan-Jansen, Editor(s)

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