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Proceedings Paper

Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters
Author(s): Yueqing Gu; Vincent Bourke; Jae Gwan Kim; Mengna Xia; Anca Constantinescu; Ralph P. Mason; Hanli Liu
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Paper Abstract

Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO2, tumor vascular oxygenated hemoglobin concentration [HbO2], and tumor oxygen tension pO2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY) to evaluate dynamic responses of breast tumors to carbogen (5% CO2 and 95% O2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO2, followed by changes in global tumor vascular [HbO2], and delayed responses for pO2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.

Paper Details

Date Published: 29 July 2003
PDF: 8 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.479465
Show Author Affiliations
Yueqing Gu, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwest Medical Ctr. at Dallas (United States)
Vincent Bourke, Univ. of Texas Southwest Medical Ctr. at Dallas (United States)
Jae Gwan Kim, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwest Medical Ctr. at Dallas (United States)
Mengna Xia, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwest Medical Ctr. at Dallas (United States)
Anca Constantinescu, Univ. of Texas Southwest Medical Ctr. at Dallas (United States)
Ralph P. Mason, Univ. of Texas Southwest Medical Ctr. at Dallas (United States)
Hanli Liu, Univ. of Texas at Arlington (United States)
Univ. of Texas Southwest Medical Ctr. at Dallas (United States)


Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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