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Proceedings Paper

Ultrasensitive diode-laser-based monitor for singlet oxygen
Author(s): Steven J. Davis; Leyun Zhu; Ahmed M. Minhaj; Michael F. Hinds; Seonkyung Lee; Philip B. Keating; David I. Rosen; Tayyaba Hasan
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Paper Abstract

In this paper we present results from experiments to develop a real-time, optical monitor for singlet molecular oxygen produced during photodynamic therapy. Using a pulsed diode laser and a sensitive photomultiplier tube, we have obtained signals from singlet oxygen during and following pulsed laser excitation. Several photosensitizers were used, and we obtained strong signals even in the presence of protein laden environments. Values obtained for the lifetimes of the singlet oxygen state and the photosensitizer triplet state are compared to literature values.

Paper Details

Date Published: 13 June 2003
PDF: 9 pages
Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); doi: 10.1117/12.479433
Show Author Affiliations
Steven J. Davis, Physical Sciences Inc. (United States)
Leyun Zhu, Physical Sciences Inc. (United States)
Ahmed M. Minhaj, Physical Sciences Inc. (United States)
Michael F. Hinds, Physical Sciences Inc. (United States)
Seonkyung Lee, Physical Sciences Inc. (United States)
Philip B. Keating, Physical Sciences Inc. (United States)
David I. Rosen, Physical Sciences Inc. (United States)
Tayyaba Hasan, Wellman Labs. of Photomedicine/Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 4952:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII
David Kessel, Editor(s)

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