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Proceedings Paper

Photodynamic therapy of breast cancer with photosense
Author(s): Elena G. Vakoulovskaya; Victor V. Shental; Loubov V. Oumnova; Georgiu N. Vorozhcsov
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Paper Abstract

Photodynamic Therapy (PDT) using photosensitizer Photosense (PS) in dose 0.5 mg per kg of body weight have been provided in 24 patients with breast cancer. In 22 patients with T1-T2N0M0 primary tumor was treated as the preoperative treatment, radical mastectomy has been fulfilled 7-10 days after PDT with subsequent histological examination. 2 patients had recurrencies of breast cancer with lymph node metastases after radiotherapy. Fluorescent diagnostics of tumor, accumulation of PS in tumor, adjacent tissue, skin before and during PDT was fulfilled with spectranalyzer LESA-01. We used semiconductive laser for PDT - λ = 672+2nm, P=1,5 W, interstitial irradiation 2-24 hours after PS injection has been done in light dose 150-200 J/cm3, 1-3 irradiations with interval 24-48 hours and total light dose 400-600 J/cm3 depending mostly of size and fluorescent data. Partial regression of tumor with pathomorphosis of 2-4 degrees has been found in 19 cases. Our experience shows pronounced efficacy of PDT for treating breast cancer as preoperative modality and as palliation in cases of recurrencies.

Paper Details

Date Published: 13 June 2003
PDF: 3 pages
Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); doi: 10.1117/12.479431
Show Author Affiliations
Elena G. Vakoulovskaya, N.N. Blokhin Cancer Research Ctr. (Russia)
Victor V. Shental, N.N. Blokhin Cancer Research Ctr. (Russia)
Loubov V. Oumnova, State Scientific Ctr. NIOPIK (Russia)
Georgiu N. Vorozhcsov, State Scientific Ctr. NIOPIK (Russia)


Published in SPIE Proceedings Vol. 4952:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII
David Kessel, Editor(s)

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