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Proceedings Paper

Blinded recognition of optical coherence tomography images of human mucosa precancer
Author(s): Felix I. Feldchtein; Natalia D. Gladkova; Ludmila Snopova; Elena Zagaynova; Olga Streltzova; Andrei Shakhov; Anna Terentjeva; Natalia M. Shakhova; Irina A. Kuznetsova; Grigory V. Gelikonov; Valentin M. Gelikonov; Vladislav A. Kamensky; Ekaterina Donchenko
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Paper Abstract

In vivo endoscopic optical coherence tomography (OCT) was performed in 154 patients with pathologic lesions, suspicious for high-grade dysplasia, intramucosal or early microinvasive cancer. One group of seven physicians and another of six, familiar with OCT, participated in the blinded recognition of benign and neoplastic conditions in different types of mucous membranes. The result for the OCT sensitivity for malignancy detection in these types of mucosa is 83 - 98%, specificity 71 - 91%. The accuracy was 81 - 87%. Recognition error rate is smaller for high-grade dysplasia and invasive cancer in urinary bladder (3.3% - 1.5%), and higher for the uterine cervix (23% - 11%) and for larynx (45.7% - 3.4%). The kappa coefficient for interobserver agreement was 0.65-0.83.

Paper Details

Date Published: 8 July 2003
PDF: 6 pages
Proc. SPIE 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, (8 July 2003); doi: 10.1117/12.478926
Show Author Affiliations
Felix I. Feldchtein, Institute of Applied Physics (Russia)
Imalux Corp. (Russia)
Natalia D. Gladkova, Nizhny Novgorod Medical Academy (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Elena Zagaynova, Nizhny Novgorod Medical Academy (Russia)
Olga Streltzova, Nizhny Novgorod Regional Hospital (Russia)
Andrei Shakhov, Nizhny Novgorod Medical Academy (Russia)
Anna Terentjeva, Nizhny Novgorod Medical Academy (Russia)
Natalia M. Shakhova, Institute of Applied Physics (Russia)
Irina A. Kuznetsova, Nizhny Novgorod Regional Hospital (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Vladislav A. Kamensky, Institute of Applied Physics (Russia)
Ekaterina Donchenko, Nizhny Novgorod Research Institute for Traumatology and Orthopedics (Russia)

Published in SPIE Proceedings Vol. 4956:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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