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Proceedings Paper

Construction of an integrated biomodule composed of microfluidics and digitally controlled microelectrodes for processing biomolecules
Author(s): Patrick F. Wagler; Uwe Tangen; Thomas Maeke; Harald P. Mathis; John S. McCaskill
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Paper Abstract

This work focuses on the development of an online programmable microfluidic bioprocessing unit (BioModule) using digital logic microelectrodes for rapid pipelined selection and transfer of DNA molecules and other charged biopolymers. The design and construction technique for this hybrid programmable biopolymer processing device is presented along with the first proof of principle functionality. The electronically controlled collection, separation and channel transfer of the biomolecules is monitored by a sensitive fluorescence setup. This hybrid reconfigurable architecture couples electronic and biomolecular information processing via a single module combination of fluidics and electronics and opens new fields of applications not only in DNA computing and molecular diagnostics but also in applications of combinatorial chemistry and lab-on-a-chip biotechnology to the drug discovery process. Fundamentals of the design and silicon-PDMS-based construction of these electronic microfluidic devices and their functions are described as well as the experimental results.

Paper Details

Date Published: 17 January 2003
PDF: 7 pages
Proc. SPIE 4982, Microfluidics, BioMEMS, and Medical Microsystems, (17 January 2003); doi: 10.1117/12.478558
Show Author Affiliations
Patrick F. Wagler, Fraunhofer Research Unit for Biomolecular Information Processing (Germany)
Uwe Tangen, Fraunhofer Research Unit for Biomolecular Information Processing (Germany)
Thomas Maeke, Fraunhofer Research Unit for Biomolecular Information Processing (Germany)
Harald P. Mathis, Fraunhofer Research Unit for Biomolecular Information Processing (Germany)
John S. McCaskill, Fraunhofer Research Unit for Biomolecular Information Processing (Germany)


Published in SPIE Proceedings Vol. 4982:
Microfluidics, BioMEMS, and Medical Microsystems
Holger Becker; Peter Woias, Editor(s)

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