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Proceedings Paper

Time-frequency analysis of functional optical mammographic images
Author(s): Randall Locke Barbour; Harry L. Graber; Christoph H. Schmitz; Frank Tarantini; Georges Khoury; David J. Naar; Thomas F. Panetta; Theophilus Lewis; Yaling Pei
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Paper Abstract

We have introduced working technology that provides for time-series imaging of the hemoglobin signal in large tissue structures. In this study we have explored our ability to detect aberrant time-frequency responses of breast vasculature for subjects with Stage II breast cancer at rest and in response to simple provocations. The hypothesis being explored is that time-series imaging will be sensitive to the known structural and functional malformations of the tumor vasculature. Mammographic studies were conducted using an adjustable hemisheric measuring head containing 21 source and 21 detector locations (441 source-detector pairs). Simultaneous dual-wavelength studies were performed at 760 and 830 nm at a framing rate of ~2.7 Hz. Optical measures were performed on women lying prone with the breast hanging in a pendant position. Two class of measures were performed: (1) 20- minute baseline measure wherein the subject was at rest; (2) provocation studies wherein the subject was asked to perform some simple breathing maneuvers. Collected data were analyzed to identify the time-frequency structure and central tendencies of the detector responses and those of the image time series. Imaging data were generated using the Normalized Difference Method (Pei et al., Appl. Opt. 40, 5755-5769, 2001). Results obtained clearly document three classes of anomalies when compared to the normal contralateral breast. 1) Breast tumors exhibit altered oxygen supply/demand imbalance in response to an oxidative challenge (breath hold). 2) The vasomotor response of the tumor vasculature is mainly depressed and exhibits an altered modulation. 3) The affected area of the breast wherein the altered vasomotor signature is seen extends well beyond the limits of the tumor itself.

Paper Details

Date Published: 29 July 2003
PDF: 12 pages
Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); doi: 10.1117/12.478231
Show Author Affiliations
Randall Locke Barbour, SUNY/Downstate Medical Ctr. (United States)
NIRx Medical Technologies, LLC (United States)
Harry L. Graber, SUNY/Downstate Medical Ctr. (United States)
Christoph H. Schmitz, SUNY/Downstate Medical Ctr. (United States)
Frank Tarantini, Staten Island Univ. Hospital (United States)
Georges Khoury, Staten Island Univ. Hospital (United States)
David J. Naar, Staten Island Univ. Hospital (United States)
Thomas F. Panetta, Staten Island Univ. Hospital (United States)
Theophilus Lewis, SUNY/Downstate Medical Ctr. (United States)
Yaling Pei, NIRx Medical Technologies LLC (United States)

Published in SPIE Proceedings Vol. 4955:
Optical Tomography and Spectroscopy of Tissue V
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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